Tregs protect the body from attack by T cells
Regulatory T cells (Tregs) suppress inflammation and keep T cells and other compartments of the immune system from attacking our own body.
Cellenkos is a clinical-stage biotechnology company developing allogeneic, tissue-directed, cord blood-derived T-regulatory cell therapies to resolve inflammation in autoimmune, neurodegenerative and inflammatory diseases.
Our science
Regulatory T cells (Tregs) suppress inflammation and keep T cells and other compartments of the immune system from attacking our own body.
Defective Tregs can no longer protect the body from the harmful effect of T cells, leading to autoimmune diseases including lupus, multiple sclerosis and rheumatoid arthritis, inflammatory disorders like Crohn's disease, and bone marrow failure syndromes like aplastic anemia.
Clinically manufactured using Cellenkos' proprietary CRANE® platform from a single qualified umbilical cord blood unit, Cellenkos' Treg product shows superior T cell suppression and anti-inflammatory properties.
Infusion of Cellenkos' Treg product replaces the defective Tregs and protects the body from T cell attack — releasing IL-10, consuming IL-2 that fuels aggressive T cells, and neutralizing antigen-presenting cells.
By preventing T cell attack against one's own body, Cellenkos' Treg product helps restore immune homeostasis — creating the conditions for disease control and tissue recovery.
The CRANE® platform
CRANE® generates disease-specific Treg products enriched for homing markers, so each candidate travels directly to the tissue where unresolved inflammation drives disease. Select a program to trace its route.
CK0803
Engineered to express high levels of CXCR3 and CD11a (LFA-1), CK0803 cells are designed to traffic across the blood-brain and blood-spinal cord barriers and migrate along CXCL10 gradients toward inflamed microglia.
Our pipeline
All product candidates are investigational and have not been approved by the FDA for any indication.
News center
Publications
Cellenkos' clinical and preclinical research on cord blood-derived Tregs has been published in NEJM Evidence, Blood, Blood Advances, Annals of Internal Medicine, iScience, Cytotherapy, Cells and Frontiers journals, and presented at the American Society of Hematology Annual Meeting.
Clinical safety and preliminary efficacy of regulatory T cells for ALS
Dose intensive regimen of CK0804 Tregs in myelofibrosis
Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE
CXCR4-enriched T regulatory cells preferentially home to bone marrow and resolve inflammation
Cord blood T regulatory cells synergize with ruxolitinib to improve GVHD outcomes
Phase 1 study of CK0801 in treatment of bone marrow failure syndromes
A phase Ib, open-label study of add-on therapy with CK0804 in participants with myelofibrosis and suboptimal response to ruxolitinib
Randomized, double-blinded, placebo-controlled trial of allogeneic cord blood T-regulatory cells for treatment of COVID-19 ARDS
Allogeneic cord blood regulatory T cells decrease dsDNA antibody and improve albuminuria in systemic lupus erythematosus
Adjunct therapy with T regulatory cells decreases inflammation and preserves the anti-tumor activity of CAR T cells
Allogeneic cord blood regulatory T cells can resolve lung inflammation
Regulatory T cells: treatment for COVID-19?
Regulatory T cells for treating patients with COVID-19 and acute respiratory distress syndrome: two case reports
Ex vivo fucosylation of third-party human regulatory T cells enhances anti–graft-versus-host disease potency in vivo
Third-party umbilical cord blood-derived regulatory T cells prevent xenogenic graft-versus-host disease
Ex vivo expanded umbilical cord blood T cells maintain naive phenotype and TCR diversity

Join our team
We are growing our footprint in the Houston life sciences ecosystem. If you work in cell therapy manufacturing, clinical operations, translational science or quality, we would like to hear from you.
Send us your CVOr email your CV to contact@cellenkosinc.com
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